Journal article
Separating the wheat from the chaff: Systematic identification of functionally relevant noncoding variants in ADHD
JHS Tong, Z Hawi, C Dark, TDR Cummins, BP Johnson, DP Newman, R Lau, A Vance, HS Heussler, N Matthews, MA Bellgrove, KC Pang
Molecular Psychiatry | SPRINGERNATURE | Published : 2016
DOI: 10.1038/mp.2016.2
Abstract
Attention deficit hyperactivity disorder (ADHD) is a highly heritable psychiatric condition with negative lifetime outcomes. Uncovering its genetic architecture should yield important insights into the neurobiology of ADHD and assist development of novel treatment strategies. Twenty years of candidate gene investigations and more recently genome-wide association studies have identified an array of potential association signals. In this context, separating the likely true from false associations ('the wheat' from 'the chaff') will be crucial for uncovering the functional biology of ADHD. Here, we defined a set of 2070 DNA variants that showed evidence of association with ADHD (or were in link..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
We acknowledge the financial support of the following agencies: the Australian National Health and Medical Research Council (NHMRC) (Project IDs 1064591 and 1065677, and Fellowship ID 520574 (KCP)), Australian Research Council (Future Fellowship (MAB)), Royal Australasian College of Physicians and the Menzies Foundation. We would also like to acknowledge the Queensland Brain Bank and the Victorian Brain Bank for providing the non-pathological brain tissue samples. These centres are funded by the NHMRC. Tissues were also obtained from the New South Wales Tissue Resource Centre at the University of Sydney, which is supported by the NHMRC, Schizophrenia Research Institute and National Institute of Alcohol Abuse and Alcoholism (NIH (NIAAA) R24AA012725).